The Watson lab is located in the Research Unit of Dr Olivier Delattre , whose focus is the characterization of molecular lesions in pediatric tumors (sarcoma, neuroblastoma, rhabdoid tumors) and adult sarcomas.
Sarcomas consist of a group of malignant tumors of mesenchymal origin with major clinical, pathological and biological heterogeneity. Over the last decades, major advances in molecular biology and genetics have led to the dismantlement of multiples subtypes of sarcomas characterized by specific molecular alterations, including gene fusions, activating mutations and epigenetic alterations. We perform translational research on adult soft tissue sarcomas coming from patients treated in Institut Curie. Our goals are to understand the molecular bases governing inter/intra tumor heterogeneity and mesenchymal oncogenesis, using multiple Next Generation Sequencing approaches (RNAseq, WES, single-cell RNAseq, ChiPSeq) and validation in animal and cell line models.
VIB#4 – Understating of melanoma biology – the mechanisms underlying melanoma initiation, growth, metastatic dissemination, emergence of inter-and intra-tumor heterogeneity, plasticity and resistance to therapyemerald_SCS2021-09-16T13:30:10+00:00