The lab: Khodosevich group
Lab's research themes:
We study mechanisms that are responsible for neuronal specification, positioning and circuit formation during brain development, and how these mechanisms are impaired in neurodevelopmental disorders, such as schizophrenia, epilepsy, autism and others. In particular, we investigate how genetics and environment shape brain development and determine the vulnerability of neurons to developmental disorders.
Merits of the lab:
Strong expertise in high resolution technologies to study developmental mechanisms, including single cell and spatial omics, both wet- and dry-lab, as well as functional techniques for characterization of neuronal cells and circuits during development and maturation.
Why do we want medical doctors?
Our research group has experience with MD candidates and holds close collaborations with the clinic in several research projects.
The position
What’s the main purpose of our research?
We aim to address the key questions for our understanding of brain function “how such a complex organ as the brain is built up during development?” and “what goes wrong in neurodevelopmental disorders?” For the selected EMERALD fellow, we propose a project that aims to understand the impact of severe maternal respiratory tract infections on fetal brain development and offspring behavior.
How we will do it?
Using single-cell and spatial omics as well as functional readouts, such as behavior and calcium imaging.
Why is this important?
The project will identify if there is any risk for the offspring from maternal respiratory infections to developmental disorders. Given the high spread of severe respiratory infections nowadays and that any epidemiologic studies for maternal effects in humans will take years, the study will provide an essential overview of what to expect from maternal respiratory infections and prepare the healthcare system for any consequences.
Who is a good fit for the project?
Experience in molecular biology, animal modelling, virology, and brain development will be highly valuable.
We expect that if we see the phenotype in the animal model, it will be related to psychiatric disorders, thus psychiatrists might be most interested in this position.
Other positions
- IDIBAPS#4 – Mechanisms involved in strenuous exercise-induced atrial myocardial fibrosisDavid Brena2022-06-02T10:51:50+00:00
IDIBAPS#4 – Mechanisms involved in strenuous exercise-induced atrial myocardial fibrosis
- IC#4 – The role polyglutamylation in tauopathic neurodegenerationDavid Brena2022-05-18T16:35:32+00:00
IC#4 – The role polyglutamylation in tauopathic neurodegeneration
- IC#3 – Evaluation of the efficiency of immunotherapy by tracing ctDNA in metastatic NSCLC and triple-negative breast cancer patientsDavid Brena2022-05-18T16:17:43+00:00
IC#3 – Evaluation of the efficiency of immunotherapy by tracing ctDNA in metastatic NSCLC and triple-negative breast cancer patients
- IC#2 – New targetable vulnerabilities for the treatment of chemoresistant breast and ovarian BRCA1/2-mutated tumorsDavid Brena2022-05-25T10:09:18+00:00
IC#2 – New targetable vulnerabilities for the treatment of chemoresistant breast and ovarian BRCA1/2-mutated tumors
- IDIBAPS#3 – Mechanisms involved in vascular inflammation/remodeling in systemic vasculitisDavid Brena2022-05-17T10:38:48+00:00
IDIBAPS#3 – Mechanisms involved in vascular inflammation/remodeling in systemic vasculitis
- IDIBAPS#2 – Mechanisms and therapies for Myeloma, amyloidosis, macroglobulinemia and other gammapathiesDavid Brena2022-05-24T08:49:06+00:00
IDIBAPS#2 – Mechanisms and therapies for Myeloma, amyloidosis, macroglobulinemia and other gammapathies
- IDIBAPS#1 – Developing and investigating computing, machine learning and physiological modelling for understanding each individual heart towards personalised medicineDavid Brena2022-05-17T10:37:53+00:00
IDIBAPS#1 – Developing and investigating computing, machine learning and physiological modelling for understanding each individual heart towards personalised medicine
- BRIC#6 – Tumour evolution, heterogeneity, and understanding of the mutational processes leading to aggressive diseaseDavid Brena2022-05-12T16:57:52+00:00
BRIC#6 – Tumour evolution, heterogeneity, and understanding of the mutational processes leading to aggressive disease
- IC#1 – The role of RNASE1 in lung metastatic niche establishment by breast cancer cellsemerald_SCS2022-05-17T13:59:30+00:00
IC#1 – The role of RNASE1 in lung metastatic niche establishment by breast cancer cells
- MDC#3 – Neuromuscular and Cardiovascular Cell Biologyemerald_SCS2022-05-17T12:04:54+00:00
MDC#3 – Neuromuscular and Cardiovascular Cell Biology
- MDC#2 – Molecular and cellular basis of behavioremerald_SCS2022-05-17T12:05:10+00:00
MDC#2 – Molecular and cellular basis of behavior
- MDC#1 – Host-microbiome factors in cardiovascular diseaseemerald_SCS2022-05-17T12:05:25+00:00
MDC#1 – Host-microbiome factors in cardiovascular disease
- NKI#1 – Epigenetic regulation in hormone-driven cancers and therapy resistanceemerald_SCS2022-05-19T08:58:30+00:00
NKI#1 – Epigenetic regulation in hormone-driven cancers and therapy resistance
- VIB#8 – Mechanisms of inflammation and associated tissue damage in musculoskeletal diseasesemerald_SCS2022-05-16T20:44:33+00:00
VIB#8 – Mechanisms of inflammation and associated tissue damage in musculoskeletal diseases
- VIB#7 – Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and validationemerald_SCS2022-05-16T20:32:47+00:00
VIB#7 – Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and validation
- VIB#6 – Cellular metabolism and metabolic regulation in cancer metastasisemerald_SCS2022-05-18T08:52:10+00:00
VIB#6 – Cellular metabolism and metabolic regulation in cancer metastasis
- VIB#5 – Unraveling the molecular mechanisms of neuronal degeneration in motor neuron diseasesemerald_SCS2022-05-16T19:39:35+00:00
VIB#5 – Unraveling the molecular mechanisms of neuronal degeneration in motor neuron diseases
- VIB#4 – Identification of universal biomarkers of metastatic melanoma in CTCsemerald_SCS2022-05-18T08:43:51+00:00
VIB#4 – Identification of universal biomarkers of metastatic melanoma in CTCs
- VIB#3 – Basic mechanisms of Alzheimer’s disease and neurodegenerationemerald_SCS2022-05-16T19:54:56+00:00
VIB#3 – Basic mechanisms of Alzheimer’s disease and neurodegeneration
- VIB#2 – Integrative genomics to underpinning somatic evolution, tumour heterogeneity, and treatment resistanceemerald_SCS2022-05-15T23:07:12+00:00
VIB#2 – Integrative genomics to underpinning somatic evolution, tumour heterogeneity, and treatment resistance
- VIB#1 – Medical biotechnology to improve hepatocellular carcinoma diagnosticsemerald_SCS2022-05-24T08:33:04+00:00
VIB#1 – Medical biotechnology to improve hepatocellular carcinoma diagnostics
- BRIC#5 – The impact of severe maternal respiratory tract infections on fetal brain development and offspring behavioremerald_SCS2022-05-19T18:49:58+00:00
BRIC#5 – The impact of severe maternal respiratory tract infections on fetal brain development and offspring behavior
- BRIC#7 – Understanding and overcoming drug resistance in acute myeloid leukemiaemerald_SCS2022-05-24T08:43:03+00:00
BRIC#7 – Understanding and overcoming drug resistance in acute myeloid leukemia
