We study mechanisms that are responsible for neuronal specification, positioning and circuit formation during brain development, and how these mechanisms are impaired in neurodevelopmental disorders, such as schizophrenia, epilepsy, autism and others. In particular, we investigate how genetics and environment shape brain development and determine the vulnerability of neurons to developmental disorders.
Merits of the lab:
Strong expertise in high resolution technologies to study developmental mechanisms, including single cell and spatial omics, both wet- and dry-lab, as well as functional techniques for characterization of neuronal cells and circuits during development and maturation.
Why do we want medical doctors?
Our research group has experience with MD candidates and holds close collaborations with the clinic in several research projects.
We aim to address the key questions for our understanding of brain function “how such a complex organ as the brain is built up during development?” and “what goes wrong in neurodevelopmental disorders?” For the selected EMERALD fellow, we propose a project that aims to understand the impact of severe maternal respiratory tract infections on fetal brain development and offspring behavior.
How we will do it?
Using single-cell and spatial omics as well as functional readouts, such as behavior and calcium imaging.
Why is this important?
The project will identify if there is any risk for the offspring from maternal respiratory infections to developmental disorders. Given the high spread of severe respiratory infections nowadays and that any epidemiologic studies for maternal effects in humans will take years, the study will provide an essential overview of what to expect from maternal respiratory infections and prepare the healthcare system for any consequences.
Who is a good fit for the project?
Experience in molecular biology, animal modelling, virology, and brain development will be highly valuable.
We expect that if we see the phenotype in the animal model, it will be related to psychiatric disorders, thus psychiatrists might be most interested in this position.
IDIBAPS#1 – Developing and investigating computing, machine learning and physiological modelling for understanding each individual heart towards personalised medicineDavid Brena2022-05-17T10:37:53+00:00