The lab: Andersen group
Lab's research themes:
We focus on clinical solutions in liver and bile duct cancers to unravel perturbed mechanisms required for these tumors to develop, to grow and to metastasize. Our research programs include integrative omics-driven patient characterization and stratification, biomarker discovery, epigenetic therapy, inflammatory and immune deregulation and metabolic diseases. We are always interested in extending our biological understanding of the liver and hepatobiliary system, learning and/or collaborating on new research areas helping us alleviate clinic problems.
Merits of the lab:
The Andersen group have extensive collaborations worldwide, and Dr. Andersen is co-founder of the European Network for the Study of Cholangiocarcinoma – ENSCCA (www.enscca.org).
Why do we want medical doctors?
Our research group is multidisciplinary, hosting both a wet-lab and bioinformatic sections. The group is multi-lingual, -ethnic and gender-diverse. Past MD PhD students have already graduated. Our main collaborators are national and international clinicians.
The position
What’s the main purpose of our research?
We aim to study the epigenetics, metabolic rearrangements and gene regulation in hepatobiliary diseases (epi-metabolic deregulation).
How we will do it?
To tackle these questions, we will use a wide variety of top-notch methodologies in biomedical research, such as omics data, genetic editing in primary cell lines and organoids, as well as bioinformatics.
Why is this important?
Metabolic liver diseases causing cancer are increasing, and our biological understanding, as well as therapeutic options, are limited. Uncharted research areas are the interplay between epigenetics and metabolism as well as manipulating vital signalling molecules in the tumor microenvironment (TME). Genetically modifying central genes, e.g. controlling the metabolic regulation, will allow us to start to understand the biology and consequence of the disease progression. This knowledge is crucial to improve diagnosis, patient stratification and design novel treatment options.
Who is a good fit for the project?
Experience in hepatology (liver cancer and NAFLD), as well as programming skills in R or similar languages.
Other positions
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IDIBAPS#4 – Mechanisms involved in strenuous exercise-induced atrial myocardial fibrosis
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IC#4 – The role polyglutamylation in tauopathic neurodegeneration
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IC#3 – Evaluation of the efficiency of immunotherapy by tracing ctDNA in metastatic NSCLC and triple-negative breast cancer patients
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IC#2 – New targetable vulnerabilities for the treatment of chemoresistant breast and ovarian BRCA1/2-mutated tumors
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IDIBAPS#3 – Mechanisms involved in vascular inflammation/remodeling in systemic vasculitis
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IDIBAPS#2 – Mechanisms and therapies for Myeloma, amyloidosis, macroglobulinemia and other gammapathies
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IDIBAPS#1 – Developing and investigating computing, machine learning and physiological modelling for understanding each individual heart towards personalised medicine
- BRIC#6 – Tumour evolution, heterogeneity, and understanding of the mutational processes leading to aggressive diseaseDavid Brena2022-05-12T16:57:52+00:00
BRIC#6 – Tumour evolution, heterogeneity, and understanding of the mutational processes leading to aggressive disease
- IC#1 – The role of RNASE1 in lung metastatic niche establishment by breast cancer cellsemerald_SCS2022-05-17T13:59:30+00:00
IC#1 – The role of RNASE1 in lung metastatic niche establishment by breast cancer cells
- MDC#3 – Neuromuscular and Cardiovascular Cell Biologyemerald_SCS2022-05-17T12:04:54+00:00
MDC#3 – Neuromuscular and Cardiovascular Cell Biology
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MDC#2 – Molecular and cellular basis of behavior
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MDC#1 – Host-microbiome factors in cardiovascular disease
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NKI#1 – Epigenetic regulation in hormone-driven cancers and therapy resistance
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VIB#8 – Mechanisms of inflammation and associated tissue damage in musculoskeletal diseases
- VIB#7 – Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and validationemerald_SCS2022-05-16T20:32:47+00:00
VIB#7 – Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and validation
- VIB#6 – Cellular metabolism and metabolic regulation in cancer metastasisemerald_SCS2022-05-18T08:52:10+00:00
VIB#6 – Cellular metabolism and metabolic regulation in cancer metastasis
- VIB#5 – Unraveling the molecular mechanisms of neuronal degeneration in motor neuron diseasesemerald_SCS2022-05-16T19:39:35+00:00
VIB#5 – Unraveling the molecular mechanisms of neuronal degeneration in motor neuron diseases
- VIB#4 – Identification of universal biomarkers of metastatic melanoma in CTCsemerald_SCS2022-05-18T08:43:51+00:00
VIB#4 – Identification of universal biomarkers of metastatic melanoma in CTCs
- VIB#3 – Basic mechanisms of Alzheimer’s disease and neurodegenerationemerald_SCS2022-05-16T19:54:56+00:00
VIB#3 – Basic mechanisms of Alzheimer’s disease and neurodegeneration
- VIB#2 – Integrative genomics to underpinning somatic evolution, tumour heterogeneity, and treatment resistanceemerald_SCS2022-05-15T23:07:12+00:00
VIB#2 – Integrative genomics to underpinning somatic evolution, tumour heterogeneity, and treatment resistance
- VIB#1 – Medical biotechnology to improve hepatocellular carcinoma diagnosticsemerald_SCS2022-05-24T08:33:04+00:00
VIB#1 – Medical biotechnology to improve hepatocellular carcinoma diagnostics
- BRIC#5 – The impact of severe maternal respiratory tract infections on fetal brain development and offspring behavioremerald_SCS2022-05-19T18:49:58+00:00
BRIC#5 – The impact of severe maternal respiratory tract infections on fetal brain development and offspring behavior
- BRIC#7 – Understanding and overcoming drug resistance in acute myeloid leukemiaemerald_SCS2022-05-24T08:43:03+00:00
BRIC#7 – Understanding and overcoming drug resistance in acute myeloid leukemia
